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Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestosby: Kirsten Hawkins Sarcomatoid Mesothelioma is a quite uncommon type of cancer caused due to asbestos exposure. While it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases. The possibility of finding this type of cancer is on the lips and the larynx. However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, this cancer is a fatal disease and hardly responds to any method of treatment. Even though radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment. Diagnosis of Sarcomatoid Mesothelioma: The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma. For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1). The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings. Latest Cancer News:Taking Aim at Brain Cancer (Forbes) Smarter matching of drugs to patients is likely to improve on the lukewarm results seen so far with targeted cancer therapies. Hot dogs cast as villain in cancer group's ad (USA Today) A new TV commercial shows kids eating hot dogs in a school cafeteria and one little boy's haunting lament: "I was dumbfounded when the doctor told me I have late-stage colon cancer." 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News) In an Aug. 26 story about a new TV ad linking hot dogs with cancer, The Associated Press, relying on figures provided by a nutrition adviser to the American Institute for Cancer Research, erroneously reported average risks for colon cancer and how eating hot dogs affects those risks. Karen Collins said she misstated the average adult's lifetime risk for getting colorectal cancer, which is about ... Cancer spread 'happens earlier' (BBC News) Apparently "normal" cells may carry cancer to new sites long before a tumour develops, scientists say. Cervical Cancer Rate May Fall in Poor Nations With Tests, Shots (Bloomberg.com) Aug. 28 (Bloomberg) -- New screening methods and immunization shots are making it possible to control the number of cervical cancer cases in developing countries for the first time, researchers said in a Vaccine medical journal report. E! Standing Up To Cancer Too (Broadcasting and Cable) Entertainment network joins ABC, CBS and NBC in broadcasting 'Stand Up To Cancer' special. Mun2, E! Step Up to ?Stand Up to Cancer? (TV Week) Mun2 and E! Entertainment Television are joining other networks in airing the charity special ?Stand Up to Cancer? on Sept. 5 at 8 p.m. ? Stand Up to Cancer ,? put together by the Entertainment Industry Foundation, will air live simultaneously on ABC, CBS and NBC and will feature appearances by several celebrities and performers in an effort to raise funds for cancer research. Correction: Hot Dogs-Cancer story - The Associated Press
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